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泡沫硬化疗法是治疗下肢静脉曲张的主要方法之一,了解泡沫稳定性的影响因素有助于减少治疗的副作用,达到最好的治疗效果。实验中选用5mL注射器,液气比1∶4,环境温度为20℃,进行了9组不同推注速度的实验。全程摄像,每组重复实验5次,对稳定性指标(析水时间、半衰期、泡沫半衰期体积量和析水率曲线)进行对比分析。结果显示,推注速度从100~275mm/s逐渐增大时,泡沫的析水时间和半衰期呈现升高的趋势;高于275mm/s之后,则呈下降趋势。析水时间最大差异高达340.0%,半衰期最大差异为118.8%。同时,由于压强随推注速度的增加而增大,使得二氧化碳溶解度增大,进而导致泡沫半衰期体积量减少。因此,采用Tessari法制备泡沫硬化剂时,推注速度对泡沫稳定性有显著的影响。随着推注速度增大,泡沫衰变机制由气体扩散为主变为排液为主,使得泡沫稳定性先增高后减小。研究结果显示275mm/s为最佳推注速度。
Foam sclerotherapy is one of the main ways to treat varicose veins of the lower extremities. Understanding the factors that influence foam stability can help reduce the side effects of treatment and achieve the best possible outcome. In the experiment, 5 mL syringes were selected, the liquid-gas ratio was 1: 4 and the ambient temperature was 20 ℃. Nine experiments of different injection velocities were carried out. Throughout the experiment, repeated experiments were conducted five times in each group, and the stability indexes (water analysis time, half-life, foam half-life volume and water rate curve) were compared and analyzed. The results showed that the time and the half-life of the foam showed a trend of increasing when the injection speed increased from 100-275 mm / s. The maximum difference in water analysis time was as high as 340.0% and the maximum half-life difference was 118.8%. At the same time, as the pressure increases with the increase of the injection speed, the solubility of carbon dioxide increases, which leads to the reduction of the volume of foam half-life. Therefore, when using the Tessari method to prepare a foam hardener, the rate of injection has a significant effect on foam stability. With the increase of the bolting speed, the bubble decay mechanism mainly changes from gas diffusion to draining, which makes the foam stability first increase and then decrease. The results show that 275mm / s is the best injection speed.