肺动脉高压是以血管增殖重塑、原位血栓形成、肺血管床进行性闭塞、肺血管阻力进行性增高为特征的肺小动脉疾病。其发病机制是一个复杂的、多因素参与的过程。近来越来越多的研究表明,肺脏血管内皮功能障碍在肺动脉高压形成的起始及发展阶段都起着重要作用。正常的肺脏血管内皮 Pulmonary hypertension is a pulmonary arteriolar disease characterized by proliferation and remodeling of blood vessels, in situ thrombosis, progressive obstruction of the pulmonary vascular bed and progressive increase of pulmonary vascular resistance. Its pathogenesis is a complex and multi-factor involved process. Recently, more and more studies have shown that pulmonary vascular endothelial dysfunction plays an important role in the initiation and development of pulmonary hypertension. Normal lung vascular endothelium