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充血性心衰的治疗虽有了较大的进展,但死亡率仍在50～54％,近半数人的死因不是由于心衰本身,而由于并发心律失常所致。一、发生机理 (一)心肌本身的病变:心肌炎症、变性、坏死、缺血、缺O,心肌特性的改变,以及Ca代谢异常等可直接引起心脏起搏或传导上的障碍导致心律失常。其中以急性心肌梗塞时最常发生而且性质严重,由室壁瘤或心室发育不全引起者往往顽固难治。心肌缺血使心肌能量供应不足,肌浆网摄取Ca~(++)减少,导致舒张延迟,加重心肌缺血形成恶性循环。
Although the treatment of congestive heart failure has made great progress, but the mortality rate is still 50 ~ 54%, nearly half of the cause of death is not due to heart failure itself, but due to concurrent arrhythmia. First, the mechanism of occurrence (a) of the myocardium’s own lesions: myocardial inflammation, degeneration, necrosis, ischemia, lack of O, changes in myocardial characteristics, and abnormal Ca metabolism can lead directly to cardiac pacing or conduction disorders lead to arrhythmia. One of the most common and acute myocardial infarction occurs in nature, caused by aneurysm or ventricular hypoplasia are often stubborn refractory. Myocardial ischemia myocardial energy supply, sarcoplasmic reticulum uptake of Ca ~ (++) decreased, leading to delayed relaxation, increased myocardial ischemia formed a vicious cycle.