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人类白细胞抗原(human leukocyte antigens,HLA)位于6号染色体短臂上,包括多个基因座位,每个基因座位上有多个等位基因。HLA复合体在机体防御病原体入侵、器官移植配型、自体免疫和某些疾病关联等方面具有重要意义[1]。HLA基因分型已广泛应用于多个领域,如群体遗传多态性研究、实体器官和造血干细胞移植供受者组织相容性配型、某些疾病的关联和人类遗传进化等[2-3]。本文在常规的实
Human leukocyte antigens (HLA) are located on the short arm of chromosome 6 and include multiple loci, with multiple alleles per locus. HLA complex in the body defense against pathogen invasion, organ transplantation matching, autoimmune and some diseases related to the significance of [1]. HLA genotyping has been widely used in many fields, such as population genetic polymorphism, solid organ and hematopoietic stem cell transplantation recipients histocompatibility matching, the association of certain diseases and human genetic evolution [2-3 ]. This article is in the conventional reality