实验性5-对氟苯氧基伯喹柠檬酸盐(MP-0090)毒性试验对狗、猴及小鼠的心肌、肝脏和部分动物的脑进行了病理观察,并与等剂量的磷酸伯喹进行对比。观察结果为二者均可引起部分狗及小鼠的心肌轻度嗜酸性变,部分狗的肝脏有灶性气球样变及个别猴有脂肪变。上述病变均属可逆并无临床意义,此外,两种药物所引起的损害基本相似。 Experimental toxicity test of 5-p-fluorophenoxyquat citrate (MP-0090) Pathological examination was performed on the brains, liver and some animals’ brains of dogs, monkeys and mice, and the same dose of propranolol comparing. The observation that the two can cause mild eosinophilic changes in some dogs and mice myocardial, part of the dog’s liver with focal balloon-like changes and individual monkeys with steatosis. The above lesions are reversible and have no clinical significance, in addition, the damage caused by the two drugs are basically similar.