Sjogren-Larrson综合征是一种由遗传决定的综合征,常染色体隐性遗传,有三个主要征候:先天性鱼鳞病、痉挛性双肢/四肢麻痹和智力缺陷。已有报告本综合征病人具有皮纹型的改变如:变异猿线、双轴三叉及轴三叉远侧移位、atd角增大和小鱼际型发生率增加等。本文报告35例Sjogren-LarrsOn综合征 Sjogren-Larrson syndrome is a genetically determined syndrome autosomal recessive with three main symptoms: congenital ichthyosis, spastic limbs / limbs paralysis and mental retardation. It has been reported that patients with this syndrome have dermal changes such as: variant ape line, biaxial trigeminal and axial trigeminal distraction, atd angle increases and the occurrence of small intestine type increased. This article reports 35 cases of Sjogren-LarrsOn syndrome