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近年来出凝血功能的深入研究,推动了治疗方法的进展。新生儿及婴儿早期出凝血系统处于不断的发育过程之中,生理变异较大,与成人相比,出凝血系统中各种蛋白因子的浓度,转换率以及调节功能均不同。因此必须掌握不同时期的特点,才能作出正确的判断。凝血方面凝血因子不能通过胯盘,胎儿在最初三个月开始自行合成。第19～27周的胎儿血中已测得大部份凝血因子,含量甚微,随胎令渐增。出生时已具备所有凝血因子,浓度大都低于成人值。各因子的差异并不均一,如Vitk依赖因子(Ⅱ,Ⅶ,Ⅸ,Ⅹ)和启动因子(Ⅺ,Ⅻ,PK,HMWK)都低于70%的成人值;而因子Ⅰ,Ⅴ,Ⅷ,ⅩⅢ及VWF都高于70%的
In recent years, in-depth study of coagulation, promote the progress of treatment. Early neonatal and infant coagulation system is in the process of continuous development, physiological variation, compared with adults, the coagulation system in a variety of protein factor concentration, conversion rate and regulatory functions are different. Therefore, we must grasp the characteristics of different periods in order to make the right judgments. Clotting factor coagulation factor can not pass the hip plate, the fetus in the first three months to start their own synthesis. Fetal blood from 19 to 27 weeks has been measured in most of the blood clotting factor, content is minimal, with fetal order increased. Have all the clotting factors at birth, mostly below adult levels. The differences among the factors were not uniform. For example, the values of Vitk-dependent factors (Ⅱ, Ⅶ, Ⅸ and Ⅹ) and the promoters (Ⅺ, Ⅻ and PK and HMWK) XIII and VWF are higher than 70%