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Objective To analyze the effect of interleukin 1 beta-ILl B-511C ＞ T polymorphism on lipid-lowering effect of rosuvastatin in patients with coronary heart disease (CHD) combined with acute respiratory viral infection (ARVI).Methods Lipid spectrum,concentrations of C-reactive protein and interleukin 1 beta were analyzed,genotyping of IL-1 beta ILl B-511C ＞ T polymorphism (rs16944) using polymerase chain reaction was provided in 119 patients with CHD combined with ARVI,and in control group of 313 patients suffering from CHD without viral infection from Kursk region.Results Statistically significant increase in total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels was determined in patients with CHD combined with ARVI.The effectiveness of TC and LDL-C reduction using rosuvastatin was less pronounced in this group in comparison with patients without ARVI.Conclusion Comparative analysis of the frequencies of alleles in the genotype of interleukin 1 beta-ILl B-511C ＞ T in patients with CHD combined with ARVI and with CHD without ARVI,reveals no differences.