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采用自身对照法评价大剂量甲氨喋呤（ＨＤＭＴＸ）对１７例处于完全缓解期小儿急性淋巴细胞白血病的治疗效果。结果：均无水肿、少尿、高血压、血尿等症状，治疗前后血尿素氮、肌酐无显著性差异，治疗后尿２４小时蛋白定量显著升高（Ｐ＜０．０５），但仅３例次＞０．２０ｇ／２４ｈ，血尿β２微球蛋白均显著增加（Ｐ＜０．０５），肾图异常率２３．１％，均为排泄减缓，双肾平均指数与血β２微球蛋白呈负相关，说明肾图、β２微球蛋白是反映甲氨喋呤肾损害较敏感的指标，应用ＨＤＭＴＸ有良好的耐受性。
To evaluate the therapeutic effect of high-dose methotrexate (HDMTX) in 17 children with acute lymphoblastic leukemia in complete remission by using self-control method. Results: No edema, oliguria, hypertension, hematuria and other symptoms before and after treatment, blood urea nitrogen, creatinine no significant difference, 24 hours after treatment, urine protein increased significantly (P <0.05), but only 3 cases Times> 0.20g / 24h, hematuria and β2 microglobulin were significantly increased (P <0.05), renal abnormalities were 23.1%, were excretion slowed down, the average index of both kidneys and blood β2 microglobulin was negative Correlation, indicating that the kidney map, β2 microglobulin is a more sensitive indicator of renal damage caused by methotrexate, the application of HDMTX have good tolerance.