对甲砜苯甲醛(P-Methylsulfonylbenzaldehyde)是生产甲砜霉素(Thiampheniocl)的起始原料。在国外,也是生产β-内酰胺抗菌剂、荧光增白剂、二氢吡啶衍生物类抗心绞痛药物,及生产抗炎抗风湿类药物等方面的重要中间体。按起始原料或工艺条件的不同,对甲砜苯甲醛的合成方法图解如右: 目前工业生产对甲砜苯甲醛皆以甲苯为原料,与氯磺酸反应得到对甲苯磺酰氯和邻甲苯磺酰氯,后者用于生产糖精。对甲苯磺酰氯经亚硫酸钠处理和甲基化后得到对甲砜甲苯。早期氧化对甲砜甲苯为对甲砜苯甲醛采用铬酐氧化法,工艺繁杂,后处理困 P-Methylsulfonylbenzaldehyde is the starting material for the production of thiamphenicol. Abroad, but also the production of β-lactam antibacterial agents, optical brighteners, dihydropyridine derivatives of anti-anginal drugs, and the production of anti-inflammatory anti-rheumatoid drugs and other important intermediates. According to the different starting materials or process conditions, the synthesis of methyl sulfoxide benzaldehyde is illustrated as right: At present, all the industrial production of methyl sulfone and benzaldehyde is carried out by using toluene as raw material and reacting with chlorosulfonic acid to obtain p-toluenesulfonyl chloride and o- Acid chlorides, the latter used to produce saccharin. Para-toluenesulfonyl chloride is treated with sodium sulfite and methylated to yield methyl sulfone toluene. Oxidation of methyl sulfone toluene to methyl sulfone benzaldehyde using chromic anhydride oxidation, complex process, post-processing difficulties