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随着人们和医生们的普遍注意,以及遗传咨询和超声检查的临床应用,大家都认识到足月前无脑儿畸形的百分率是比较高的。但是对于终止足月近20周以后无脑儿妊娠,目前尚无满意的方法。近年来Brenner(1975)报道证实了应用前列腺素E_2(简称PGE_2)及前列腺素F_(2α)(简称PGF_(2α))能够有效地终止各个孕龄期的妊娠。虽然阴道应用PGE_2以及羊膜腔内应用PGF_(2α)可以做中期妊娠的引产,但对于终止末期妊娠效果是不肯定的。由于子宫肌随着孕龄对前列腺素敏感性的增高,因此当中期妊娠时使用一般引产PGF_(2α)剂量时,常导致子宫过度兴奋和并发症。
With the widespread attention of people and doctors, as well as the clinical application of genetic counseling and ultrasound, we all recognize that the percentage of brainless deformities before term is relatively high. However, there is no satisfactory way to stop brain contraception after nearly 20 weeks in term. In recent years, Brenner (1975) confirmed that the application of prostaglandin E_2 (PGE_2) and prostaglandin F_ (2α) (PGF_ (2α) for short) can effectively terminate gestational pregnancies. Although vaginal use of PGE_2 and intra-amniotic administration of PGF_ (2α) can lead to induction of labor in the second trimester, its effect on the termination of terminal pregnancy is uncertain. As the uterine muscle with gestational age prostaglandin sensitivity increased, so when the use of general induction of labor induced labor PGF 2 (2α) dose, often lead to uterine hyperexcitability and complications.