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近期研究表明干细胞在形态、分子以及功能上都存在两种明显特殊形式:以鼠源胚胎干细胞为代表的一类白血病抑制因子依赖性多能状态,以及鼠类外胚层干细胞为代表的纤维母细胞生长因子依赖性原始多能状态。在鼠源外胚层干细胞培养条件下诱导性多潜能干细胞的诱导取决于纤维母细胞生长因子,研究发现纤维母细胞生长因子诱导性多潜能干细胞意外地表现出类胚胎干细胞或内细胞群的性能。纤维母细胞生长因子诱导性多潜能干细胞有X染色体活性、多遗传性分化、畸胎瘤潜能以及在有机体内的嵌合能力。调查结果表明在129和B16鼠系中,无论出于何种生长因子环境下,诱导性多潜能干细胞都能保持原始多能状态。关键分子信号通路的描述说明纤维母细胞生长因子诱导性多潜能干细胞有赖于活化素和纤维母细
Recent studies have shown that there are two distinct and specific forms of stem cells in morphology, molecule and function: a type of leukemia inhibitory factor-dependent pluripotent state represented by murine embryonic stem cells, and fibroblasts represented by murine ectodermal stem cells Growth factor-dependent primitive pluripotent state. The induction of induced pluripotent stem cells under murine ectodermal stem cell culture depends on the expression of fibroblast growth factor and it has been found that fibroblast growth factor induced pluripotent stem cells unexpectedly show the performance of embryonic stem cells or inner cell populations. Fibroblast growth factor-induced pluripotent stem cells have X-chromosome activity, multiple genetic differentiation, teratoma potential and chimerism in the organism. The findings indicate that induced pluripotent stem cells retain their primitive pluripotent state in both 129 and B16 murine lines regardless of the growth factor environment. Description of Key Molecular Signaling Pathway Fibroblast Growth Factor Inducible Pluripotent Stem Cells Dependent on Activin and Fibroblast