Cannabis sativa,is also popularly known as marijuana,has been cultivated and used for recreational and medicinal purposes for many centuries.The main psychoactive content in cannabis is △9-tetrahydrocannabinol (THC).In addition to plant cannabis sativa,there are two classes of cannabinoids—the synthetic cannabinoids (e.g.,WIN55212-2) and the endogenous cannabinoids (eCB),anandamide (ANA) and 2-arachidonoylglycerol (2-AG).The biological effects of cannabinoids are mainly mediated by two members of the G-protein-coupled receptor family,cannabinoid receptors 1 (CB1R) and 2 (CB2R).The endocannabinoids,cannabinoid receptors,and the enzymes/proteins responsible for their biosynthesis,degradation,and re-updating constitute the endocannabinoid system.In recent decades,the endocannabinoid system has attracted considerable attention as a potential therapeutic target in numerous physiological conditions,such as in energy balance,appetite stimulation,blood pressure,pain modulation,embryogenesis,nausea and vomiting control,memory,leaing and immune response,as well as in pathological conditions such as Parkinsons disease,Huntingtons disease,Alzheimers disease,and multiple sclerosis.