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目的：观察急性心肌梗死（ Ａ Ｍ Ｉ）患者静脉溶栓前后早期血浆降钙素基因相关肽（ｃ Ｇ Ｒ Ｐ）、内皮素（ Ｅ Ｔ）和血清一氧化氮（ Ｎ Ｏ）水平的变化。方法：采用放射免疫法和比色分析法分别对静脉溶栓前后血管再通组（３０ 例），与未通组（２２ 例）的 Ａ Ｍ Ｉ患者及 ２０ 例正常人上述 ３ 种血管活性物质进行检测。结果： Ａ Ｍ Ｉ时患者ｃ Ｇ Ｒ Ｐ 再通组（３８６４±７１４）ｎｇ／ Ｌ，未通组（３２９８±１００７）ｎｇ／ Ｌ； Ｎ Ｏ 再通组（１８７１±３５６）μｍ ｏｌ／ Ｌ，未通组（１４８５±４０４）μｍ ｏｌ／ Ｌ； Ｅ Ｔ再通组（１３２６２±３１６３）ｎｇ／ Ｌ，未通组（１６７３３±３０６１）ｎｇ／ Ｌ；对照组分别为（５２９４±１４１７）ｎｇ／ Ｌ、（２１１７±６３４）μｍ ｏｌ／ Ｌ和（６６６５±１０６３）ｎｇ／ Ｌ，未通组较再通组变化更为明显。溶栓后１２ 小时，各组ｃ Ｇ Ｒ Ｐ、 Ｎ Ｏ 有所回升，但未通组ｃ Ｇ Ｒ Ｐ仍显著低于再通组（ Ｐ＜ ００５）；再通组 Ｅ Ｔ 继续升高，未通组则开始下降。溶栓后２４ 小时，２ 组ｃ Ｇ Ｒ Ｐ和 Ｎ Ｏ 继续升高，再通组 Ｅ Ｔ 下降，未通组则略有升高。结论：血浆ｃ Ｇ Ｒ Ｐ?
AIM: To observe the changes of plasma CGRP, ET and NO levels in patients with acute myocardial infarction (AMI) before and after venous thrombolysis. Methods: Radioimmunoassay and colorimetric analysis were used to evaluate the effects of intravenous thrombolysis in 30 patients with recanalization before and after thrombolysis, 22 with AMI and 20 with normal controls. The above three vasoactive substances Test. Results: At the time of A M I, the levels of cG R P recanalization (3864 ± 714) ng / L, unfertile (3298 ± 1007) ng / L, N o recanalization 71 ± 356) μm ol / L in the failed group (1485 ± 404) μm ol / L, 132.72 ± 3163 ng / L in the ET recanalization group, (16733 ± 3061) ng / L, respectively. The control group were (5294 ± 1417) ng / L, (2117 ± 634) μmol / L and (6665 ± 10) 63) ng / L, failed to change the group than the recanalization group more obvious. At 12h after thrombolysis, the levels of cG R P and N O increased in all groups, but the values of c G R P in non-through group were still significantly lower than those in recanalization group (P <005) , Failed group began to decline. Twenty-four hours after thrombolysis, cG R P and N O continued to increase in both groups, while E T decreased in the recanalization group and slightly increased in the failed group. Conclusion: Plasma c G R P?