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致癌的HPV感染与宫颈癌的发生相关联。 HPV癌蛋白E_6和E_7分别与p53蛋白及视网膜母细胞易感基因产物相互作用在宫颈癌的发生中发挥了决定性作用。E_6蛋白与p53蛋白结合并促进其降解。p53基因进化保守区域的突变亦可改变p53的功能。
Carcinogenic HPV infection is associated with the development of cervical cancer. The interaction of HPV oncoproteins E_6 and E_7 with p53 and retinoblastoma gene products plays a decisive role in the development of cervical cancer. E_6 protein binds to p53 protein and promotes its degradation. Mutations in the conserved region of the p53 gene also alter the function of p53.