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目的:观察艾司洛尔对大面积烧伤切削痂术中应用肾上腺素液湿敷创面止血的心血管反应平抑效果。方法:30例大面积烧伤切痂手术患者随机分为实验组与对照组,每组15例,实验组患者在创面应用肾上腺素液湿敷时给予艾司洛尔,对照组则给予生理盐水,记录2组患者在肾上腺素盐水湿敷前1min(T0),湿敷后1min(T1),5min(T2),10min(T3),15min(T4),30mim(T5)不同时点的平均动脉压(MBP),心率(HR)。结果:对照组T2,T3,T4的MBP及HR较T0时点有显著性增加(P<0.01),实验组T0,T2,T3,T4的MBP及HR各时点差异均无显著性(P>0.05),实验组与对照组间在T2,T3,T4时点的MBP,HR有显著性增加(P<0.01)。结论:艾司洛尔对烧伤创面肾上腺素液湿敷止血的心血管反应有很好的平抑作用。
Objective: To observe the effect of esmolol on the cardiovascular response to hemostasis induced by epinephrine wet compress in extensive burns and cutting-off operation. Methods: Thirty patients with extensive burn escharectomy were randomly divided into experimental group and control group, with 15 cases in each group. Estrool was given in the experimental group when the application of adrenaline fluid was wet and the control group was given normal saline, The mean arterial pressure (MAP) at different time points after 1 min (T0), 1 min (T1), 5 min (T2), 10 min (T3), 15 min (T4) and 30 mim (T5) (MBP), heart rate (HR). Results: The MBP and HR of T2, T3 and T4 in control group were significantly higher than those at T0 (P <0.01). There was no significant difference in MBP and HR at T0, T2, T3 and T4 in experimental group > 0.05). The MBP and HR of experimental group and control group at T2, T3 and T4 were significantly increased (P <0.01). CONCLUSION: Esmolol has a good suppressive effect on the cardiovascular response to epidural anesthesia in burn wounds.