目的:建立微波消解-石墨炉原子吸收光度法测定二丙酸倍他米松中铬含量的方法。方法:采用微波消解法对二丙酸倍他米松样品进行消解,通过石墨炉程序升温法在波长357.9 nm下进行含量测定。结果:回归方程A=0.024983C+0.003,r=0.998 9,线性范围为0～40 ng/mL;方法检测限为0.012 mg/kg,定量限为0.036 mg/kg;平均回收率为102.0%(n=6)。结论:该方法检测二丙酸倍他米松中铬含量灵敏、准确、可靠。 Objective: To establish a method for the determination of chromium content in betamethasone dipropionate by microwave digestion - graphite furnace atomic absorption spectrometry. Methods: The samples of betamethasone dipropionate were digested by microwave digestion and the content of betamethasone dipropionate was determined by graphite furnace temperature-programmed method at the wavelength of 357.9 nm. Results: The regression equation was 0.024983C + 0.003, r = 0.998 9, linear range was 0-40 ng / mL. The detection limit was 0.012 mg / kg and the limit of quantification was 0.036 mg / kg. The average recovery was 102.0% n = 6). Conclusion: The method for the determination of betamethasone dipropionate chromium content sensitive, accurate and reliable.