论文部分内容阅读
目的:研究外周血Toll受体2(TLR2)和Toll受体9(TLR9)在小儿复发性单纯疱疹(RHS)中的作用。方法:选择从2014年1月至2016年12月在我院就诊的RHS患儿46例纳入本次研究,将其记为观察组。另选同期在我院进行健康体检的儿童45例作为对照组。对比两组外周血TLR2及TLR9水平,白细胞介素-2(IL-2)、白细胞介素-4(IL-4)及C反应蛋白(CRP)水平,采用Spearman相关性分析患儿外周血TLR2及TLR9水平与其炎症指标的相关性。结果:观察组外周血TLR2、TLR9和TLR2及TLR9双表达的水平均明显高于对照组(P<0.05)。观察组的IL-2水平较对照组降低(P<0.05),IL-4及CRP水平较对照组升高(P<0.05)。Spearman相关性分析显示,患儿外周血TLR2及TLR9水平与其IL-2呈负相关(P<0.05),与IL-4和CRP呈正相关(P<0.05)。结论:TLR2和TLR9在RHS患儿外周血中均具有较高表达,且与机体炎症因子IL-2、IL-4及CRP间具有紧密联系,值得临床重视。
Objective: To investigate the role of peripheral blood Toll Receptor 2 (TLR2) and Toll Receptor 9 (TLR9) in children with recurrent herpes simplex (RHS). Methods: Forty-six patients with RHS who were treated in our hospital from January 2014 to December 2016 were enrolled in this study, which were recorded as observation group. In the same period, 45 cases of children undergoing physical examination in our hospital were selected as the control group. The level of TLR2 and TLR9, the levels of IL-2, IL-4 and CRP in peripheral blood were compared between the two groups. Spearman correlation analysis was used to analyze the correlation between TLR2 And TLR9 levels and its correlation with inflammation. Results: The double expression levels of TLR2, TLR9, TLR2 and TLR9 in the observation group were significantly higher than those in the control group (P <0.05). The level of IL-2 in the observation group was lower than that in the control group (P <0.05), while the level of IL-4 and CRP in the observation group was higher than that of the control group (P <0.05). Spearman correlation analysis showed that the levels of TLR2 and TLR9 in peripheral blood were negatively correlated with IL-2 (P <0.05), positively correlated with IL-4 and CRP (P <0.05). CONCLUSION: TLR2 and TLR9 are highly expressed in peripheral blood of children with RHS, and are closely related to IL-2, IL-4 and CRP, which deserves clinical attention.