论文部分内容阅读
为探讨细胞外间质主要成分透明质酸（ＨＡ）与层粘连蛋白（ＬＮ）在缺血性股骨头坏死（ＩＮＦＨ）中的生理病理过程及临床价值，采用放射免疫分析法对４５例不同病因的ＩＮＦＨ患者进行了血清ＨＡ与ＬＮ的定量分析，并与３０例正常人对照。结果显示，ＩＮＦＨ患者血清ＨＡ含量极显著地高于对照组（ｔ＝３－２９；Ｐ＜０－０１）。尤以激素性ＩＮＦＮ增高最为显著（ｔ＝３－６２；Ｐ＜０－０１）。ＩＮＦＨ患者ＬＮ含量亦明显高于对照组（ｔ＝２－８４；Ｐ＜０－０１）。同时，ＨＡ与ＬＮ含量增高与病程发展密切相关。故定量检测ＨＡ与ＬＮ可作为ＩＮＦＨ早期诊断及判断预后的良好指标
To investigate the physiological and pathological process and clinical value of hyaluronic acid (HA) and laminin (LN), the main components of extracellular matrix, in ischemic necrosis of the femoral head, the radioimmunoassay Of INFH patients with serum HA and LN quantitative analysis, and 30 cases of normal controls. The results showed that serum HA levels in patients with INFH were significantly higher than those in the control group (t = 3-29; P <0-01). In particular, the most significant increase in hormone INFN (t = 3-62; P <0-01). The LN level in patients with INFH was also significantly higher than that in the control group (t = 2-84; P <0-01). At the same time, HA and LN content is closely related to the course of disease development. Therefore quantitative detection of HA and LN can be used as a good indicator of early diagnosis and prognosis of INFH