胃肠道肿瘤是临床最常见的肿瘤 ,死亡率高 ,预后差 ,人们为攻克这一顽症进行了几个世纪的努力。 6 0年代 Sug-im ur等 [1 ] 用甲基硝基亚硝基胍 (MNNG)诱发大鼠胃腺癌获得成功 ,开创了人类利用动物研究人类癌肿诊治的前景。 70年代人癌细胞株的建立及裸鼠移植瘤的成功 ,使肿瘤 Gastrointestinal neoplasms are the most common tumors in the clinic. Mortality is high and prognosis is poor. People have been working hard to overcome this chronic disease for centuries. In the 1960s, Sug-im ur et al. [1] succeeded in inducing rat gastric adenocarcinoma with methyl nitrosoguanidine (MNNG), which opened the prospect of human beings’ use of animals in the diagnosis and treatment of human cancer. The establishment of human cancer cell lines in the 1970s and the success of xenograft tumors in nude mice