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观察了鳖甲煎口服液对实验性肝纤维化的治疗作用。应用四氯化碳复合因素造模后选取血清谷丙转氨酶 (AL T)、碱性磷酸酶 (AL P)、乳酸脱氢酶 (L DH)活性、透明质酸 (HA)、血清白蛋白 (AL B)及组织学变化作为测定指标并与秋水仙碱作比较 ,进行实验。结果表明鳖甲煎口服液与金匮鳖甲煎丸一样对实验性肝纤维化有明显的治疗作用。它能提高血清 AL B含量 ,使 AL T、 AL P、 L DH活性下降 ,HA含量下降 ,门脉高压降低 ,调整免疫功能而使脾重减轻。
The therapeutic effect of Biejiajian Oral Liquid on experimental liver fibrosis was observed. Serum levels of alanine aminotransferase (AL T), alkaline phosphatase (AL P), lactate dehydrogenase (L DH) activity, hyaluronic acid (HA), serum albumin were selected after modeling with carbon tetrachloride. AL B) and histological changes were used as an indicator and compared with colchicine for experiments. The results showed that Biejiajian Oral Liquid had the same therapeutic effect on experimental hepatic fibrosis as Jinqi Jiabao Pill. It can increase the serum AL B content, so that AL T, AL P, L DH activity decreased, HA content decreased portal pressure decreased, adjust the immune function and reduce spleen weight.