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前列腺素的生物活性非常广泛,它对cAMP的合成、血小板凝集、脂类代谢、激素分泌都有影响,因此,认为它参与辐射损伤的调节作用,特别对造血的调节作用。已证明它抑制造血的增殖而对CFU—S的分化有刺激作用。在体外培养中,前列腺素抑制定向造血干细胞的生长。为了阐明前列腺素在造血型放射病综合征中的作用,作者研究了抑制前列腺素生物合成对受照小鼠造血恢复的作用。实验使用520只(CBA和C5781杂交)F_1代雄性小鼠,体重24～26克。一次照射~(60)Co—γ射线6或7戈
The biological activity of prostaglandins is very extensive. It affects the synthesis of cAMP, platelet aggregation, lipid metabolism, and hormone secretion. Therefore, it is considered to be involved in the regulation of radiation damage, especially the regulation of hematopoiesis. It has been shown to inhibit the proliferation of hematopoietic cells and have a stimulatory effect on the differentiation of CFU-S. In vitro, prostaglandins inhibit the growth of targeted hematopoietic stem cells. To elucidate the role of prostaglandins in hematopoietic radiation sickness syndrome, the authors studied the effect of prostaglandin biosynthesis on hematopoietic recovery in irradiated mice. The experiment used 520 F1 hybrid male mice (CBA and C5781 hybrids) weighing 24-26 g. One shot of 60 Co-γ rays 6 or 7 Ge