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文章简介耐药性金黄色葡萄球菌感染常成为临床治疗的难点,这迫切需要我们发展新型的抗感染药物。抗毒力治疗是一种潜在的替代策略,该策略通过靶向细菌生长非必需的毒力因子,理论上能在降低感染的同时减少选择性压力,将大大降低细菌耐药性的出现。Ser/Thr磷酸酶Stp1是金黄色葡萄球菌毒力表达的一个重要调控因子,探讨Stp1是否是可成药的抗毒力靶点显得尤
Article introduction Drug-resistant Staphylococcus aureus infection often become the clinical treatment of the difficulties, which urgently need us to develop new anti-infective drugs. Toxicity treatment is a potential alternative strategy that, by targeting virulence factors that are not necessary for bacterial growth, theoretically reduces selective stress while reducing infection and will greatly reduce the emergence of bacterial resistance. Ser / Thr Phosphatase Stp1 Staphylococcus aureus virulence is an important regulator of expression, to explore whether Stp1 is a drug can be drug-resistant targets appear particularly