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目的:调查与分析妊娠期妇女地中海贫血的流行病学。方法:收集重庆渝北区人民医院2012年1月-2014年12月接诊的1500例产前检查并分娩的育龄期妇女,回顾分析育龄期妇女的临床资料,行血常规检查。通过红细胞的6个基本参数:红细胞,血红蛋白,红细胞压积,红细胞平均体积,红细胞平均血红蛋白量和红细胞平均血红蛋白浓度进行初筛,对初筛阳性者进一步做血红蛋白成分分析及基因诊断。结果:1500例妊娠期妇女血常规检查中,共335例为阳性,占22.33%。对其335例进行血红蛋白成分分析,怀疑为地中海贫血者为182例,占54.32%。对其182例进行基因诊断。最后,1500例妊娠期妇女中,确诊为地中海贫血者共127例,占8.46%。结论:妊娠期妇女地中海贫血发病率较高,加强其筛查必须引起足够重视。
OBJECTIVE: To investigate and analyze the epidemiology of thalassemia among pregnant women. Methods: One hundred and fifty-five prenatal women of childbearing age who received prenatal examination and deliveries from January 2012 to December 2014 in Chongqing Yubei District People’s Hospital were recruited. The clinical data of women of childbearing age were retrospectively analyzed and routine blood tests were performed. The basic parameters of red blood cells: red blood cells, hemoglobin, hematocrit, the average volume of red blood cells, erythrocyte mean hemoglobin and erythrocyte average hemoglobin concentration of the initial screen for further screening of hemoglobin positive component analysis and gene diagnosis. Results: In the blood routine examination of 1,500 pregnant women, a total of 335 cases were positive, accounting for 22.33%. He 335 cases of hemoglobin analysis, suspected of thalassemia 182 cases, accounting for 54.32%. 182 cases of its genetic diagnosis. Finally, out of 1,500 pregnant women, 127 were diagnosed with thalassemia, accounting for 8.46%. Conclusion: The prevalence of thalassemia in pregnant women is high, so screening should be paid enough attention.