目的 分析我院61例新的?严重的药品不良反应(ADR)报告的特点及规律，规范临床合理用药?方法 针对2020 年1—12 月上报的新的?严重的ADR 患者61 例，从药品种类及分布?剂型分布?累及机体系统及临床表现?ADR 报告性质及关联性评价?临床转归5 个方面进行分析?结果 西药发生ADR 的比例(88.52%)明显高于中成药(11.48%)?其中，西药中发生ADR 的药物比例最高的是抗病毒类药，共22 例(占36.06%)，其次是抗菌药物，共8 例(占3.11%)?注射剂发生ADR 的比例(62.3“,”Objective To analyze the characteristics and rules of 61 new and serious ADR reports in our hospital， and standardize the clinical rational use of drugs. Methods Focusing on 61 new and severe ADR patients reported from January to December 2020， from five aspects: drug type and distribution， dosage form distribution， system and clinical manifestations involved， ADR report nature and correlation evaluation， and clinical outcome Perform analysis. Results The rate of ADR in western medicine (88.52%) was significantly higher than that of Chinese patent medicine (11.48%). Among them， Among them， the drug with the highest proportion of ADR in Western medicine was antiviral drugs， 22 cases (36.06%)， followed by antibacterial drugs， a total of 8 cases (3.11%). The incidence of ADR in injections (62.30%) was higher than that of oral drugs (37.70%). The nervous system has the largest proportion of ADR affecting the body system， with 22 cases (36.07%)， and the respiratory system has the least occurrence of ADR， with only 1 case (1.63%). In the new and serious ADR reports， the results of relevance evaluation are mostly “probable”， accounting for 69.76% and 61.11% respectively. After the 61 cases of ADR patients were treated during the hospitalization period， 23 cases improved (37.70%) and 38 cases recovered (62.30%). Conclusion Great attention should be paid to the ADR monitoring and management of clinical western medicines， and at the same time， the use of injection-type drugs should be minimized to ensure the safe and reasonable medication of patients.