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目的 探讨IL -6、TNF -α在Graves病 (GD)中的改变。方法 3 7例GD患者在治疗前和缓解后测定血清IL -6、TNF-α水平 ,3 0例志愿者作为正常对照。结果 治疗前GD患者血清IL -6、TNF -α显著高于对照组 (P <0 0 1) ;缓解后IL -6降至正常 (P >0 0 5 ) ,但TNF -α仍高于正常 (P <0 0 1) ;治疗前GD患者血清IL -6与FT3、FT4呈正相关 ,而TNF -α与FT3、FT4无相关。结论 GD患者血清IL -6、TNF -α的变化可能与GD的发生发展有关。
Objective To investigate the changes of IL-6 and TNF-α in Graves disease (GD). Methods Thirty-seven patients with GD underwent serum IL-6 and TNF-α levels before and after treatment, and 30 volunteers as normal controls. Results Before treatment, the levels of IL-6 and TNF-α in serum of patients with GD were significantly higher than those of the control group (P <0.01); IL-6 decreased to normal (P> 0.05) (P <0.01). Before treatment, serum IL-6 in patients with GD was positively correlated with FT3 and FT4, while TNF-α had no correlation with FT3 and FT4. Conclusion The changes of serum IL-6 and TNF-α in patients with GD may be related to the occurrence and development of GD.