Bramwell等曾建议用二硝基氯苯(DNCB)皮肤试验来预测血液透析病人对乙肝疫苗的免疫应答。已有报告各种病人对乙肝疫苗的应答不一:血友病、地中海贫血和男性同性恋以及药瘾者抗体应答良好,但血液透析病人和智力迟缓者以及老年人的抗—HBs应答不良,免疫反应抑制是其可能原因。Terre等认为,即使像Down氏综合征那样的智力发育迟缓的 Bramwell et al. Suggested using the dinitrochlorobenzene (DNCB) skin test to predict the immune response to hepatitis B vaccine in hemodialysis patients. Various responses to hepatitis B have been reported in various patients: hemophilia, thalassemia and homosexual men and those with drug-eluting counterparts respond well, but hemodialysis patients and persons with mental retardation, as well as elderly people, have poor anti-HBs responses, immunizations Response inhibition is its possible cause. Terre and others think that even mental retardation like Down’s syndrome