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目的探讨分析连续性肾脏替代疗法(CRRT)疗脓毒血症急性肾损伤的有效性。方法 84例重症脓毒血症急性肾损伤患者,对其行连续性肾脏替代治疗法,并对患者治疗前后的生化指标的变化及生命体征指标进行观察分析。结果治疗后患者的心率(HR)、体温(T)低于治疗前(P<0.05);而平均动脉压(MAP)、血氧饱和度(Sp O2)明显高于治疗前(P<0.05);治疗后肌酐(Scr)、尿素氮(BUN)、K+、Na+及白细胞介素-6(IL-6)水平方面相比于治疗前明显降低(P<0.05);经后续观察分析得出,6个月内的生存率为78.57%,存活组在对应的APACHEⅡ评分相比于死亡组更低(P<0.05)。结论采用连续性肾脏替代治疗法治疗重症急性肾损伤,能有效地纠正电解质、酸碱紊乱,使患者生命体征指标趋于正常,对于提高其生存率作用重大,治疗具有有效性,应当推荐使用。
Objective To investigate the efficacy of continuous renal replacement therapy (CRRT) in the treatment of acute renal injury induced by sepsis. Methods A total of 84 patients with severe acute sepsis with acute renal injury underwent continuous renal replacement therapy. The changes of biochemical indexes and vital signs before and after treatment were observed and analyzed. Results After treatment, heart rate (HR) and body temperature (T) were lower than those before treatment (P <0.05), mean arterial pressure (MAP) and oxygen saturation (Sp O2) ; After treatment, the levels of Scr, BUN, K +, Na + and IL-6 were significantly lower than those before treatment (P <0.05) The survival rate within 6 months was 78.57%, and the corresponding APACHE II score was lower in survival group than in death group (P <0.05). Conclusion Continuous renal replacement therapy for severe acute kidney injury can effectively correct electrolytes, acid-base disorders and make the vital signs of patients tend to be normal. It is important to improve the survival rate and treat effectively. It should be recommended.