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目的 探讨胃癌组织中ｐ１６ 和Ｒｂ 蛋白的表达及其与临床病理因素的关系。方法 采用免疫组织化学方法检测了４０ 例胃癌组织中ｐ１６ 和Ｒｂ 蛋白的表达。结果 在胃癌组织中，ｐ１６ 和Ｒｂ 蛋白表达阳性率分别为３５ ．０ ％ （１４／４０） 和７２ ．５ ％ （２９／４０） ，ｐ１６ 蛋白阳性胃癌的Ｒｂ 蛋白阳性率明显低于ｐ１６ 蛋白阴性胃癌（ Ｐ＜ ０ ．０１） 。ｐ１６ 蛋白在胃癌中的表达与肿瘤组织学类型、浸润深度、淋巴结转移和ＴＮ Ｍ 分期密切相关，Ｒｂ 蛋白在胃癌中的表达与肿瘤组织学类型、淋巴结转移密切相关。结论 ｐ１６ 和Ｒｂ蛋白在胃癌中的表达下降与肿瘤的进展密切相关，ｐ１６ 和Ｒｂ 蛋白的表达相互抑制，呈明显的负相关。
Objective To investigate the expression of p16 and Rb proteins in gastric cancer tissues and their relationship with clinicopathological factors. Methods Immunohistochemistry was used to detect the expression of p16 and Rb proteins in 40 cases of gastric cancer. Results The positive rate of p16 and Rb protein expression was 35 in gastric cancer tissues, respectively. 0 % (14/40) and 72. The positive rate of Rb protein in p16-positive gastric cancer was significantly lower than that in p16-negative gastric cancer (P < 0.01) at 5 % (29/40). The expression of p16 protein in gastric cancer is closely related to the histological type, depth of invasion, lymph node metastasis and TN M stage. The expression of Rb protein in gastric cancer is closely related to histological type and lymph node metastasis. Conclusions The decreased expression of p16 and Rb proteins in gastric cancer is closely related to the progression of tumors. The expression of p16 and Rb proteins is mutually inhibited, showing a significant negative correlation.