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对34例消化性溃疡和25例正常人的血浆TXB、6-酮-PGF_1进行了测定,结果表明.溃疡组各期(?)TXB_2/6-酮-PGF_1)比值均明显高于对照组(P<0.05),溃疡组活动期患者的TXB(?)含量明显高于愈合期及对照组(P<0.05),且各期患者的6-酮—PGF含量和对照组比较无差异(P>0.05)。溃疡组中Hp组阳性及Hp阴 性患者的TXB 6-酮-PGF_1及TXB_2/6-酮-PGF_1比较均无差异(P>0.05);提示消化性溃疡存在TXB_2—PGF_1的失衡.其可能参与消化性溃疡的发病,Hp感染不影响溃疡患者血中TXB_2及PGF_1的含量 TXB_2增高可能是活动期溃疡周围炎症反应所
The plasma levels of TXB and 6-keto-PGF_1 in 34 cases of peptic ulcer and 25 normal persons were measured. The results showed that the ratio of TXB_2 / 6-keto-PGF_1 in each stage of ulcer group was significantly higher than that of control group (P <0.05). The content of TXB (?) In patients with active ulcer was significantly higher than that in the healing and control groups (P <0.05), and the levels of 6-keto-PGF in the patients with ulcer were not significantly different from those in the control group (P> 0.05). There were no significant differences in TXB 6-keto-PGF 1 and TXB 2/6-keto-PGF 1 between Hp-positive and Hp-negative patients in ulcer group (P> 0.05), suggesting that imbalance of TXB_2-PGF_1 may exist in peptic ulcer patients. The incidence of ulcer, Hp infection does not affect the blood levels of TXB_2 and PGF_1 in patients with ulcer TXB_2 increased may be active inflammation around the ulcer reaction