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目的探讨肥胖大学生体质量指数与血清同型半胱氨酸、氧化低密度脂蛋白、血脂及血糖的相关性及其临床意义。方法 2010年入学体检大学生中以自愿参加方式,将体质量指数≥25的大学生55例设为肥胖组(n=55),体质量指数<25的大学生92例设为对照组(n=92),2组学生均无急慢性内科疾患。直接竞争ELISA法测定2组血清同型半胱氨酸、氧化低密度脂蛋白水平,测定总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、血糖。结果 2组比较,肥胖组血清同型半胱氨酸高于对照组,氧化低密度脂蛋白高于对照组,差异均有统计学意义(P<0.05);肥胖组血清三酰甘油高于对照组,高密度脂蛋白低于对照组,差异有统计学意义(P<0.01);2组总胆固醇、低密度脂蛋白、血糖差异无统计学意义(P>0.05);肥胖组大学生体质量指数与血清同型半胱氨酸水平相关(r=0.321,P<0.05),体质量指数与血清氧化低密度脂蛋白水平不相关(r=0.263,P>0.05);多元线性回归分析显示,三酰甘油、同型半胱氨酸为肥胖组大学生体质量指数水平的独立影响因素。结论肥胖大学生易发生动脉粥样硬化性疾病。防治大学生肥胖及相关慢性病,是高校教育需重视的问题。
Objective To investigate the correlation between body mass index (BMI), serum homocysteine, oxidized low density lipoprotein (LDL), lipids and blood glucose in obese university students and its clinical significance. Methods Fifty-five college students with a body mass index ≥25 were enrolled as obese group (n = 55) and 92 college students with a body mass index <25 as volunteers. There was no acute or chronic medical problems in both groups. Direct competitive ELISA was used to measure serum homocysteine and oxidized low density lipoprotein levels in two groups. Total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and blood glucose were measured. Results Compared with control group, the levels of serum homocysteine in obesity group and oxidized low density lipoprotein in obese group were higher than those in control group (P <0.05). The serum triglyceride in obese group was higher than that in control group (P <0.01). There were no significant differences in total cholesterol, low density lipoprotein and blood glucose between the two groups (P> 0.05). The body mass index of college students in obesity group was significantly higher than that in control group (R = 0.321, P <0.05). There was no correlation between body mass index and serum oxidized low density lipoprotein (r = 0.263, P> 0.05). Multiple linear regression analysis showed that triglyceride , Homocysteine is an independent factor affecting the body mass index of college students in obesity group. Conclusion Obese students are prone to develop atherosclerotic disease. Prevention and treatment of college students obesity and related chronic diseases, is a problem that needs attention in higher education.