目的:探讨维吾尔医药异常黑胆质成熟剂在实验动物小鼠放射防护中的作用。方法:随机把正常实验小鼠分成对照组和异常黑胆质成熟剂药物(以下简称药物)处理组,其中药物处理组根据药物浓度分低剂量组(6.25%)、中剂量组(12.50%)和高剂量组(25.00%)。所有小鼠给予6Gy的6MV-X直线加速器全身照射1次;照射前后连续灌胃7d,然后处死10只小鼠,分别观察和检测小鼠的脾脏指数、脾脏SOD值和外周血中白细胞、红细胞以及血小板数目;余20只正常饲养到30d,观察存活率。结果:(1)药物处理组小鼠的体质量高于对照组,但差异无统计学意义(P>0.05)。对照组的脾脏指数明显高于药物处理组(P<0.01)。(2)与对照组相比,各组异常黑胆质成熟剂对受照射小鼠的SOD值有明显的升高(P<0.01),且与药物浓度呈正相关关系。(3)与对照组相比,药物组对白细胞有明显的升高作用(P<0.05),且浓度越高,白细胞数越多(P<0.001);药物干预组红细胞数与对照组相比差异有统计学意义(P<0.05);但各剂量组间无差异(P>0.05)。药物干预各组的血小板数较对照组高,但差异无统计学意义(P>0.05);随着浓度升高,血小板计数呈增多趋势,但差异无统计学意义(P>0.05)。(4)药物干预组30d生存率明显提高,且随着浓度的提高而增加,各干预组生存率与对照组相比明显提高(P<0.0001)。(5)受辐射小鼠SOD与生存率之间为线形正相关(r=0.612,P<0.0001)。受辐射小鼠白细胞与生存率之间为线形正相关(r=0.320,P<0.05)。结论:维药异常黑胆质成熟剂对于辐射动物具有明显的放射防护作用。 Objective: To investigate the role of Uighur abnormal Savda in the radioprotection of experimental mice. Methods: The normal mice were randomly divided into control group and abnormal savda mature drug treatment group. The drug treatment group was divided into low dose group (6.25%), middle dose group (12.50%) according to drug concentration, And high dose group (25.00%). All mice were given 6Gy 6MV-X linear accelerator once a whole body irradiation; Irradiation before and after continuous gavage 7d, and then killed 10 mice were observed and detected in mice spleen index, spleen SOD value and peripheral blood leukocytes, red blood cells And the number of platelets; more than 20 normal feeding to 30d, observe the survival rate. Results: (1) The body weight of the mice in the drug-treated group was higher than that of the control group, but the difference was not statistically significant (P> 0.05). The spleen index of the control group was significantly higher than that of the drug treatment group (P <0.01). (2) Compared with the control group, the abnormal savda mature agent in each group had a significant increase (P <0.01) in the SOD value of irradiated mice, and was positively correlated with the drug concentration. (3) Compared with the control group, the drug group had a significant increase in leukocyte (P <0.05), and the higher the concentration, the higher the number of white blood cells (P <0.001); the number of red blood cells in the drug intervention group was significantly higher than that in the control group The difference was statistically significant (P <0.05), but there was no difference between each dose group (P> 0.05). Compared with the control group, the number of platelets in the intervention group was higher than that in the control group, but the difference was not statistically significant (P> 0.05). With the increase of concentration, the platelet count showed an increasing trend, but the difference was not statistically significant (P> 0.05). (4) The 30-day survival rate of drug intervention group was significantly increased, and with the increase of concentration, the survival rate of each intervention group was significantly higher than that of the control group (P <0.0001). (5) There was a linear positive correlation between SOD and survival rate in irradiated mice (r = 0.612, P <0.0001). There was a linear positive correlation between leukocytes and survival rate in irradiated mice (r = 0.320, P <0.05). Conclusion: The abnormal savda of vitamin A has a significant radioprotective effect on irradiated animals.