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为了观察环孢霉素A(CyA)对以肾病综合征为表现的局灶节段性肾小球硬化 (FSGS)的疗效。对11例病儿进行治疗 ,年龄2岁～11岁。CyA开始治疗剂量3mg/ (kg·d) ,1周后加至5mg/ (kg·d) ,以后根据CyA血浓度调整剂量 ,维持CyA血浓度在100μg/L～200μg/L。用药6个月～9个月后逐渐减量 ,总疗程12个月。结果显示完全缓解7例 (63.6% ) ,部分缓解3例 (27.3 % ) ,无效1例 (9.1% ) ,CyA治疗激素耐药FSGS ,总有效率高达91 % ;5例治疗后尿视黄醇结合蛋白 (RBP)升高。提示CyA治疗以肾病综合征为表现的FSGS在临床上具有良好疗效 ,RBP则可作为CyA副作用的监测指标
To observe the effect of cyclosporine A (CyA) on focal segmental glomerulosclerosis (FSGS) as a nephrotic syndrome. 11 cases of sick children for treatment, aged 2 to 11 years old. CyA began to be treated at a dose of 3 mg / (kg · d), and after 1 week, the dose of CyA was increased to 5 mg / (kg · d). The dose of CyA was adjusted to maintain the concentration of CyA in the range of 100 μg / L to 200 μg / L. Medication 6 months to 9 months after gradual reduction, the total course of 12 months. The results showed complete remission in 7 cases (63.6%), partial remission in 3 cases (27.3%), ineffective in 1 case (9.1%), CyA treatment hormone resistant FSGS, the total effective rate as high as 91%; 5 cases of treatment of urinary retinol Binding protein (RBP) increased. The results suggest that CyA treatment of nephrotic syndrome FSGS has good clinical efficacy, RBP can be used as indicators of CyA side effects