杜邦默克制药公司的研究者采用组合化学和基于结构的配体设计方法，设计了一种新类型的化合物，它们能够抑制引起癌转移和关节炎的胶原酶。这项工作有利于获得更有效的抑制癌细胞转移和治疗关节炎的新药物。研究人员发现新的抑制剂可以诱导它们所抑制的胶原蛋白酶在活性位点产 Researchers at DuPont Merck Pharmaceuticals, using combinatorial chemistry and structure-based ligand design, have devised a new class of compounds that inhibit collagenases that cause cancer metastases and arthritis. This work is conducive to more effective inhibition of cancer cell metastasis and the treatment of arthritis new drugs. Researchers have found that new inhibitors can induce collagenase activity in the active site that they inhibit