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目的：测定小鼠在急性重复过程中脑内ＳＯＤ、ＧＳＨ－Ｐｘ活性及ＬＰＯ含量的变化，为缺氧耐受的研究提供实验依据。方法：应用急性重复缺氧的小鼠模型，测定了急性重复缺氧过程中小鼠全脑ＳＯＤ、ＧＳＨ－Ｐｘ活性和海马区ＬＰＯ含量的变化。结果：缺氧组小鼠全脑ＳＯＤ活性和海马区ＬＰＯ含量显著高于未经缺氧的对照组，全脑ＧＳＨ－Ｐｘ的活性显著低于对照组，但在缺氧４次后均趋向缺氧１次组水平。结论：脑内ＳＯＤ、ＧＳＨ－Ｐｘ活性及ＬＰＯ含量的适应性变化可能和小鼠急性重复缺氧耐受性的增强有关。
OBJECTIVE: To determine the activity of SOD, GSH-Px and the content of LPO during acute repetitive process in mice and provide the experimental evidence for the study of hypoxia tolerance. Methods: Acute repeated hypoxia mouse model was used to determine the changes of SOD, GSH-Px activity and LPO content in the hippocampus during acute repeated hypoxia in mice. Results: The activity of SOD and the content of LPO in hippocampus in hypoxic group were significantly higher than those in control group without hypoxia, and GSH-Px activity in whole brain was significantly lower than that in control group Oxygen level 1 group. CONCLUSION: The adaptive changes of SOD, GSH-Px activity and LPO content in brain may be related to the enhancement of acute repeated hypoxia tolerance in mice.