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简述氟喹诺酮类的药物相互作用研究近况，１．氟喹诺酮类可降低茶减及咖啡因的清除率、升高血药浓度，２．抗酸药及含金属离子药物可减少氟喹诺酮类的吸收、降低生物利用度；３．与非甾体类抗炎药合用可抑制ＧＡＢＡ的结合而引起中枢兴奋性反应；４．与华法令合用可延长凝血酶元时间；５．乳制品类可因与氟喹诺酮类形成络合物而减少药物吸收，降低生物利用度和血浓度。相互作用的结果是影响疗效或增加不良反应。因此，对此深入研究有利于指导新药开发和临床合理用药．
Brief introduction of fluoroquinolones drug interactions Recent developments, 1. Fluoroquinolones can reduce the tea and caffeine clearance, increased plasma concentration, 2. Antacids and metal ion-containing drugs can reduce the absorption of fluoroquinolones, reduce bioavailability; 3. In combination with non-steroidal anti-inflammatory drugs can inhibit the binding of GABA caused by the central excitatory response; 4. Combined with warfarin can extend the prothrombin time; 5. Dairy products can reduce drug absorption due to complex formation with fluoroquinolones, reducing bioavailability and blood levels. The result of interaction is to affect the efficacy or increase adverse reactions. Therefore, in-depth study is conducive to the guidance of new drug development and clinical rational use of drugs.