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将60只孕鼠随机地分成A、B、C及D组,前3组于孕笫7～13d分别口服1.0、0.1及0.05mg/kg敌枯双,而D组以0.5％羧甲基纤维素钠对照。每组留3只孕鼠自然分娩,其余者于孕20d处死,检查。发现A及B组畸胎率均非常显著地高于对照组(P<0.005),亦显著高于C组(P<0.025),其子代Fb体重在2.5～3月龄间显著低于F_d(P<0.05)。提出其阈剂量及最大无作用剂量分别为0.1mg/kg及0.05mg/kg。
Sixty pregnant rats were randomly divided into groups A, B, C and D. The first three groups were orally administered with 1.0, 0.1 and 0.05 mg / kg dwarf double on the 7th to 13th day of pregnancy, while in the D group, 0.5% carboxymethylcellulose Sodium control. Each group left three pregnant mice spontaneous childbirth, the remaining 20d pregnant in pregnancy, check. The results showed that the rate of teratogenicity in group A and B were significantly higher than that in control group (P <0.005), and significantly higher than that in group C (P <0.025). The Fb weight of their offspring was significantly lower than that of F_d (P <0.05). The proposed threshold dose and maximum non-action dose were 0.1mg / kg and 0.05mg / kg.