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目的 研究 2型糖尿病 (T2 DM)患者自主神经病变症状、心血管反射试验 (CRT)、心率变异性 (HRV)之间的关系。方法 选取 2 0 0 2 - 0 3～ 2 0 0 3- 0 5昆明医学院第二附属医院门诊及住院的 5 0例T2 DM患者 ,分为无症状 (DANS-)组和有症状 (DANS+ )组 ,CRT阴性 (CRT-)组和CRT阳性 (CRT+ )组 ,4 0例健康人为对照组 ,进行HRV频域分析。结果 DANS+ 组、DANS-组及对照组之间HRV值有明显变化 (P <0 .0 5 )。CRT-组较对照组HRV值明显改变 (P <0 0 5 ) ,而CRT+ 组较CRT-组显著改变 (P <0 0 1)。结论 HRV频域分析可以早期发现T2 DM患者自主神经病变。
Objective To study the relationship between the symptoms of autonomic neuropathy, cardiovascular reflex test (CRT) and heart rate variability (HRV) in type 2 diabetes mellitus (T2DM). Methods Totally 50 T2DM patients were enrolled in the Second Affiliated Hospital of Kunming Medical College from 2000-2003-2000-0305 and were divided into two groups: DANS-group and DANS- Group, CRT negative group and CRT positive group, and 40 healthy people as control group, HRV frequency domain analysis. Results There was a significant change in HRV between DANS + group, DANS- group and control group (P <0.05). The HRV of CRT-treated group was significantly changed compared with that of control (P <0.05), while that of CRT + was significantly changed (P <0.01). Conclusion HRV frequency domain analysis can detect T2DM patients with autonomic neuropathy.