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应用耳蜗外淋巴灌流技术、微电极技术及扫描、透射电镜技术，观察先服甲状腺素（１０ｍｇ）三次后行外淋巴灌流卡那霉素（１０－３ｇ／ｍｌ）１小时的豚鼠实验组（Ｔ／Ｋ）蜗内电位（ＥＰ），耳蜗微音电位（ＣＭ）和毛细胞的亚微结构变化，并与单纯灌流卡那霉素（１０－３ｇ／ｍｌ）的豚鼠对照组（ＫＭ）进行比较，发现３组动物ＥＰ无明显差异；实验组（Ｔ／Ｋ）的ＣＭ下降较对照组（ＫＭ）少，两者有显著差异；实验组动物外毛细胞损伤较对照组动物轻，提示甲状腺素可能直接作用于听毛细胞，减轻卡那霉素对内耳的毒副作用。
The guinea pigs in experimental group (10-3g / ml) treated with perilymph for 1 hour were observed after three doses of thyroxine (10mg) three times using cochlear extralymphatic perfusion technique, microelectrode technique, scanning and transmission electron microscope / K), and the subtypes of epicardium (EP), cochlear microphones (CM) and hair cells were compared with that of the guinea pig control group (KM) which was perfused with kanamycin (10-3g / ml) (P <0.05). There was no significant difference in the EP of the three groups of animals. The CM of the experimental group (T / K) decreased less than that of the control group (KM) May directly affect the hair cells, reduce the side effects of kanamycin on the inner ear.