随着癌症医学的发展,细胞毒性抗癌药物与放射治疗在临床上的普遍应用使癌症患者的生存率大幅提高,如49岁以下乳腺癌患者5年生存率约90%~([1])。超过70%的年轻癌症患者有生育要求~([2]),但性腺毒性治疗会对卵巢功能造成严重的不可逆性损伤。例如,乳腺癌患者经FEC或FAC方案化学药物治疗(以下简称化疗)后,闭经的发生率高达50%~65%~([3]),卵巢受到放射治疗(≥5Gy)或经造血干细胞移植前化 With the development of cancer medicine, the general clinical application of cytotoxic anticancer drugs and radiation therapy has greatly increased the survival rate of cancer patients. For example, the 5-year survival rate of breast cancer patients under 49 years old is about 90% ~ ([1]) . More than 70% of young cancer patients have fertility requirements ~ ([2]), but gonadal toxicity treatment can cause severe irreversible damage to ovarian function. For example, the incidence of amenorrhea is as high as 50% to 65% in breast cancer patients undergoing FEC or FAC chemotherapy (hereinafter referred to as chemotherapy), ovarian cancer is treated with radiation (≥5 Gy), or hematopoietic stem cell transplantation Pre-turn