目的探讨表皮粘附因子epithelialcadherinEcd表达与涎腺肿瘤的分化和临床生物学行为的关系。方法采用Ecd多克隆抗体的过氧化物酶的免疫组化检测技术。Ecd表达以细胞浆内有棕黄色颗粒为阳性,染色强度则以正常腮腺组织阳性细胞呈现的棕黄色染色特征(++)为标准。结果2例正常涎腺组织Ecd在腺泡细胞尤其在腺管系统和腺泡—腺管单位有明显表达。5例良性混合瘤均为正常表达。涎腺癌47例中,39例Ecd表达减弱或消失。高恶性涎腺癌与低恶性涎腺癌的Ecd表达有明显的差异。术前累及面神经和皮肤的11例均为Ecd表达减弱或消失。Ecd表达的减弱或消失与涎腺癌的复发、转移和5年生存率有明显的关系。结论:涎腺肿瘤组织的Ecd检测有可能作为判别其临床生物学行为和预后的指标。 Objective  To investigate the relationship between epidermal adhesion factor  epithelialcadherinE  cd expression and salivary gland tumor differentiation and clinical biological behavior. Methods  E  cd polyclonal antibody peroxidase immunohistochemical detection techniques. E  cd expression in the cytoplasm of brown-yellow particles were positive, staining intensity normal parotid gland positive cells showed brown staining (++) as a standard. Results  2 cases of normal salivary tissue E  cd in acinar cells, especially in the duct system and acinar - duct units were significantly expressed. Five cases of benign mixed tumors were normal expression. 47 cases of salivary gland cancer, 39 cases of E  cd expression decreased or disappeared. E-cd expression of high-malignant salivary gland carcinoma and low-grade salivary gland carcinoma were significantly different. Preoperative involvement of the facial nerve and skin were 11 cases of E  cd expression decreased or disappeared. E  cd expression decreased or disappeared and salivary gland cancer recurrence, metastasis and 5-year survival rate was significantly related. Conclusion: Salivary gland tumor E-cd detection may be used as an index to determine the clinical biological behavior and prognosis.