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目的探讨痰热清联合抗生素治疗对重型颅脑损伤气管切开并发肺部感染患者血清IL-13、白三烯B_4(LTB_4)水平的影响及临床意义。方法重型颅脑损伤行气管切开术后并发肺部感染患者80例,根据治疗方式分为痰热清联合抗生素治疗组(观察组)40例和单用抗生素治疗组(对照组)40例,两组疗程均为14d。治疗第1、3,7、14天测量两组患者的体温,行血常规检查了解患者血白细胞计数情况,并以酶联免疫吸附实验(ELISA)检测两组患者血清中IL-13及LTB_4水平。结果与对照组相比,观察组患者的IL-13水平在第1、3、7、14天均明显增高,而LTB_4则均明显减低(均P<0.01),观察组内不同时间点比较,均有统计学差异(均P<0.05)。治疗后第3、7、14天观察组患者的体温和治疗后第1、3、7、14天的血白细胞计数均较对照组明显降低(均P<0.01),而观察组内不同时间点比较,均有统计学差异(均P<0.05)。结论痰热清联合抗生素治疗可明显降低重型颅脑损伤气管切开并发肺部感染患者血清LTB_4水平,同时维持IL-13在较高水平,表明其可减轻患者肺部感染后的炎症反应。
Objective To investigate the effect of Tanreqing combined with antibiotics on the levels of serum IL-13 and leukotriene B 4 (LTB 4) in patients with traumatic traumatic brain injury complicated with traumatic brain injury and its clinical significance. Methods Eighty patients with severe pulmonary trauma complicated with pulmonary infection after tracheotomy were divided into 40 cases of Tanreqing combined with antibiotics (observation group) and 40 cases of single antibiotic treatment group (control group) according to the way of treatment. Two groups of treatment are 14d. The body temperature of the two groups was measured on the 1st, 3rd, 7th and 14th day after treatment. The blood leukocyte count was determined by routine blood tests. The serum levels of IL-13 and LTB_4 in the two groups were detected by enzyme-linked immunosorbent assay (ELISA) . Results Compared with the control group, the levels of IL-13 in the observation group were significantly increased on the 1st, 3rd, 7th and 14th days, while the levels of LTB_4 were significantly decreased (all P <0.01). Compared with the control group, There was statistical difference (all P <0.05). On the 3rd, 7th and 14th day after treatment, the body temperature of the observation group and the WBC counts on the 1st, 3rd, 7th and 14th days after treatment were significantly lower than those in the control group (all P <0.01) Compared with statistical differences (all P <0.05). Conclusion Tanreqing combined with antibiotics can significantly reduce the level of serum LTB_4 in patients with traumatic brain injury complicated with tracheotomy and pulmonary infection while maintaining a high level of IL-13, indicating that it can reduce the inflammatory reaction in patients with pulmonary infection.