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据2011年9月20日张辰宇(Cell Res,2011 Sep 20)报道,南京大学研究人员发现,植物的微小核糖核酸(microRNA)可以通过日常食物摄取的方式进入人体血液和组织器官。并且,一旦进入体内,它们将通过调控人体内靶基因表达的方式影响人体的生理功能,进而发挥生物学作用。微小核糖核酸是一类长约19至24个核苷酸的非编码小分子RNA,它通过与靶基因的信使RNA(mRNA)结合的方式抑制相应的蛋白质翻译。该课题组之前的研究成果表明微小核糖核酸可稳定存在于哺乳动物的血清和血浆(循环微小核糖核酸)中,是由组织和细胞主动分泌的(分泌型微小核糖核酸)。因此,循环微小核糖核酸是一类新型的疾病标志物可应用于疾病,如肿瘤的早期
According to a report by Cell Res (2011 Sep 20) on September 20, 2011, researchers at Nanjing University found that plant microRNAs can enter human blood and tissues and organs through daily food intake. And, once inside, they will have a biological effect by affecting the body’s physiological functions by regulating the expression of target genes in the body. MicroRNAs are a class of small, non-coding 19 to 24 nucleotide RNAs that inhibit the translation of a protein by binding to the target gene’s messenger RNA (mRNA). Previous research findings of the group indicate that miRNAs are stably present in mammalian serum and plasma (circulating miRNAs) and are actively secreted by tissues and cells (secreted miRNAs). Therefore, circular microRNAs are a new class of disease markers that can be applied to diseases such as early