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目的:探讨不同方案对慢性乙肝合并肺结核患者疗效及肝功能的影响。方法:选择我院2012年1月~2016年1月收治的104例慢性乙肝合并肺结核患者,随机分为观察组及对照组。观察组患者给予3HLVE/6HLE方案,对照组患者给予3HRZE/6HRE方案,观察两组患者治疗后的总有效率、肺结核改善情况、肝损伤情况、肝功能恢复时间及不良反应发生率。结果:治疗后,两组的总有效率、肺结核改善情况对比差异无统计学意义,而观察组的ALT、TBil、肝损伤发生率、严重肝损伤发生率、肝功能恢复时间及总不良反应发生率均明显低于对照组。结论:3HLVE/6HLE治疗慢性乙肝合并肺结核患者,临床疗效显著,对患者肝损伤较小,总不良反应发生低,值得临床推广应用。
Objective: To investigate the effects of different regimens on efficacy and liver function in patients with chronic hepatitis B and pulmonary tuberculosis. Methods: A total of 104 patients with chronic hepatitis B and tuberculosis who were admitted to our hospital from January 2012 to January 2016 were randomly divided into observation group and control group. Patients in observation group were given 3HLVE / 6HLE regimen. Patients in control group were given 3HRZE / 6HRE regimen. The total effective rate, improvement of pulmonary tuberculosis, liver injury, recovery time of liver function and incidence of adverse reactions in both groups were observed. Results: After treatment, there was no significant difference between the two groups in the total effective rate and in the improvement of pulmonary tuberculosis. However, ALT and TBil in the observation group, the incidence of liver injury, the incidence of severe liver injury, the recovery time of liver function and the total adverse reactions Rates were significantly lower than the control group. Conclusion: 3HLVE / 6HLE treatment of chronic hepatitis B patients with pulmonary tuberculosis, clinical significant effect on patients with small liver damage, the total adverse reactions occur low, worthy of clinical application.