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用冠状动脉Harris二期结扎并部分再灌注及吻合支缝扎法造成犬急性心肌梗塞 ,5 - 8天后 ,辅以心脏程控刺激技术 (PES)进行心电生理检查及复制快速室性心律失常 ,研制成犬在体心脏心电生理—电药理学实验模型 ,并观察了普鲁卡因胺 (PA)对该实验模型的电生理影响。结果表明 ,PA能显著延长QTc间期、RERP、NERP及IERP ,缩小IDR和VDR ,抑制心室PES诱发的室速和室颤 ,并能有效地预防犬心肌梗塞后再次急性缺血所导致的自发性室颤 ,表明PA有抗缺血性快速室性心律失常的心电生理—电药理作用。结果同时表明 ,该心电生理—电药理学实验的犬模型具有很高的可靠性、重复性及临床相关性 ,是一种有价值的评价抗快速室性心律失常药物的心电生理—电药理学方法
Acute myocardial infarction was induced by second coronary artery Harris ligation and partial reperfusion and anastomosing branch suture. After 5-8 days, cardiac electrophysiological examination (PES) and rapid ventricular arrhythmia were performed with PES, The electrophysiological-electrophysiological experimental model of canine heart was developed and the electrophysiological effects of procainamide (PA) on this experimental model were observed. The results showed that PA significantly prolonged QTc interval, RERP, NERP and IERP, reduced IDR and VDR, inhibited ventricular PES-induced ventricular tachycardia and ventricular fibrillation, and effectively prevented the spontaneous reperfusion caused by acute ischemia again after myocardial infarction in dogs Ventricular fibrillation, indicating that PA has anti-ischemic ventricular tachyarrhythmia cardiogram electrophysiological effects. The results also show that the electrophysiological electrophysiological pharmacokinetic model of the dog has a high reliability, repeatability and clinical relevance, is a valuable evaluation of anti-rapid ventricular arrhythmia drug electrophysiology Pharmacological methods