论文部分内容阅读
目的：为临床应用γ干扰素（ＩＦＮγ）防治经皮冠状动脉成形术后再狭窄提供理论依据。方法：建立兔髂动脉再狭窄动物模型，动态观察体内给予重组γ干扰素（ｒＩＦＮγ）对血管内膜平滑肌细胞（ｖＳＭＣｓ） 增生和内膜形成的抑制作用。结果：ｒＩＦＮγ可显著抑制１ 周和２ 周时内膜面积，抑制率分别为６０－００％ 和６６－６７％ ；抑制１ 周和１ 个月时内膜ｖＳＭＣｓ 表达增殖细胞核抗原，抑制率分别为８８－５０％ 和５８－８９％ 。结论：ＩＦＮγ通过抑制ｖＳＭＣｓ 的增生减少内膜的形成并可能用于临床防治再狭窄。
Objective: To provide a theoretical basis for the clinical application of interferon gamma (IFN γ) to prevent and treat restenosis after percutaneous transluminal coronary angioplasty. Methods: The animal model of iliac artery restenosis was established in rabbits. The in vivo inhibition of rIFNγ on the proliferation and intimal formation of vascular smooth muscle cells (vSMCs) was observed. Results: The rIFNγ could significantly inhibit the intima area at 1 week and 2 weeks with the inhibition rates of 60-00% and 66-67% respectively. Inhibition of proliferating cell nuclear antigen expression in vSMCs at 1 week and 1 month, inhibition rate Respectively 88-50% and 58-89%. Conclusion: IFN γ can reduce the formation of intima by inhibiting the proliferation of vSMCs and may be used for clinical prevention and treatment of restenosis.