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[目的]探讨口服血管紧张素II1型受体阻滞剂(angiotensin II type 1 receptor blockade,ARB)奥美沙坦(olmesartan)对自发性高血压大鼠(spontaneously hypertensiverats,SHR)延髓腹外侧头端(rostral ventrolateral medulla,RVLM)局部肾素血管紧张素系统(rennin-angiotensin system,RAS)的影响。[方法]雄性12周龄SHR14只,随机分成SHR组(正常饮水,n=7)及SHR-Olme组(olmesartan,10μg/(g.day),n=7),WKY组为正常血压大鼠7只(olmesartan,10μg/(g.day),n=7)。喂养4周后在延髓腹外侧头端微量注射血管紧张素II(angiotensinII,AngII),观察平均动脉压(meanarterialpressure,MAP)和心率(heartrate,HR)的变化。[结果]AngII可使SHR组MAP明显升高(+14.1±4.6mmHg),SHR-Olme组轻度升高(+3.7±1.4mmHg,),2组比较差异有统计学意义(P﹤0.05),WKY组MAP升高不明显(+2.0±0.8mmHg),与SHR组及SHR-Olme组比较,差异有统计学意义(P﹤0.05);3组心率变化差异无统计学意义。[结论]奥美沙坦能通过影响脑组织局部肾素血管紧张素系统产生降压作用。
[Objective] To explore the effect of oral olmesartan on angiotensin II type 1 receptor blockade (ARB) in spontaneously hypertensive rats (SHR) rostral ventrolateral medulla, RVLM) rennin-angiotensin system (RAS). [Methods] Male 12-week-old SHR14 rats were randomly divided into SHR group (n = 7) and SHR-Olme group (olmesartan, 10μg / 7 (olmesartan, 10 μg / (g.day), n = 7). After 4 weeks of feeding, microinjection of angiotensin II (AngII) into the rostral ventrolateral medullae to observe the change of mean arterial pressure (MAP) and heart rate (HR). [Results] The levels of MAP in SHR group were significantly increased (+14.1 ± 4.6mmHg) and slightly increased in SHR-Olme group (+ 3.7 ± 1.4mmHg, P <0.05) , MAP of WKY group was not obvious (+ 2.0 ± 0.8mmHg). There was significant difference between SHR group and SHR-Olme group (P <0.05). There was no significant difference in heart rate among 3 groups. [Conclusion] Olmesartan can produce antihypertensive effects by affecting the local renin-angiotensin system in brain tissue.