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The title compound(C21H24N4O4,Mr=396.44)has been synthesized by the functionalized ethyl 4-chloro-6-methyl-2-arylamino-furo[2,3-d]pyrimidine-5-carboxylates and morpholine.Its structure was confirmed by means of1H NMR IR,MS and elemental analysis.The crystal structure of the title compound was determined by X-ray single-crystal diffraction.The compound crystallizes in triclinic system,space group P1,a=7.9919(8),b=9.9312(1),c=12.9380(13),α=86.987(2),β=83.604(2),γ=89.641(2)°,V=1019.08(18)3,Z=2,F(000)=420,Dc=1.292 g/cm3,μ=0.091 mm 1,R=0.0602 and wR=0.1548 for 3943 independent(Rint=0.0639)and 3414 observed(I>2σ(I))reflections.Intermolecular N–H···O andπ-πstacking interactions contributed to the stability of the structure.The preliminary biological test indicated the title compound exhibited cytotoxicity against human lung cancer cell lines.
The title compound (C21H24N4O4, Mr = 396.44) has been synthesized by the functionalized ethyl 4-chloro-6-methyl-2-arylamino-furo [2,3- d] pyrimidine-5-carboxylates and morpholine.Its structure was confirmed by means 1 H NMR IR, MS and elemental analysis. The crystal structure of the title compound was determined by X-ray single-crystal diffraction. The compound crystallizes in triclinic system, space group P1, a = 7.9919 (8), b = 9.9312 Α = 86.987 (2), β = 83.604 (2), γ = 89.641 (2) °, V = 1019.08 (18) 3, Z = 2, F , Dc = 1.292 g / cm3, μ = 0.091 mm 1, R = 0.0602 and wR = 0.1548 for 3943 independent (Rint = 0.0639) and 3414 observed (I> 2σ (I)) reflections.Intermolecular N-H ··· O andπ-πstacking interactions contributed to the stability of the structure. the preliminary biological test indicated the title compound presenting cytotoxicity against human lung cancer cell lines.