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NZB 小鼠是良好的自身免疫病模型,易发生狼疮性肾炎和自身免疫性贫血。狼疮性肾炎与高免疫球蛋白血症、非器官特异性自身抗体相联系,而自身免疫性贫血与Coombs’抗体相关。NZB 小鼠产生自身抗体是由遗传所控制,如高免疫球蛋白M 血症由4号染色体上Imh-1和Imm 两个位点控制,抗-DNA,抗体由两个互不连锁的基因Ads-1,Ads-2控制,Ads-1位于17号染色体,它们与H-2-系统联系密切。重症狼疮肾炎的发生由三个基因(Lpn1,2,3)控制,它们很象是兔疫球蛋审基因。
NZB mice are a good model of autoimmune disease prone to lupus nephritis and autoimmune anemia. Lupus nephritis is associated with hyperimmunoglobulinemia and non-organ-specific autoantibodies, whereas autoimmune anemia is associated with Coombs’ antibodies. NZB mice produce autoantibodies are genetically controlled, such as high immunoglobulin M hemolytic on chromosome 4 Imh-1 and Imm two sites controlled anti-DNA, the antibody consists of two non-interlocking gene Ads -1, Ads-2 control, Ads-1 is located on chromosome 17 and they are closely linked to H-2 system. The occurrence of severe lupus nephritis is controlled by three genes (Lpn1,2,3), which are very much like the IgE gene.