论文部分内容阅读
慢性肾病(CKD)是接受异基因造血干细胞移植(allo-HSCT)后的常见并发症之一，主要与急性肾功能不全(AKI)、移植相关血栓性微血管病(TA-TMA)、移植物抗宿主病(GVHD)及BK病毒(BKV)感染等因素密切相关。CKD患者的临床表现包括膜性肾病(MN)、肾小球微小病变(MCD)、TA-TMA相关肾功能不全和BKV性肾病(BKV-N)等。对不同临床表现CKD患者采取的治疗方法不同，其预后亦不同。笔者主要从allo-HSCT后发生CKD患者的高危因素、临床特征、治疗原则、预后等方面进行阐述，以期提高临床医师对该病的认识。“,”Chronic kidney disease (CKD) is one of the common complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is closely related to acute kidney injury (AKI), transplantation-associated thrombotic microangiopathy (TA-TMA), graft versus host disease (GVHD), BK virus (BKV) infection and other factors. Main clinical manifestations of patients with CKD include membranous nephropathy (MN), minimal change disease (MCD), renal injury related TA-TMA and BKV nephropathy (BKV-N). The treatment and prognosis of CKD patients vary with the clinical manifestations. This article mainly summarizes high-risk factors, clinical characteristics, treatment principles and prognosis of patients with CKD after allo-HSCT, in order to improve the clinicians′ understanding of the disease.